The bone marrow makes a specialized set of cells. These cells are part of the acquired immune system because, after their formation, they undergo specialization. In this video, Dr. Mobeen Syed draws an imaginative comparison of the immune system with a city having soldiers manufacturing factory (bone marrow), specialized training centers for the soldiers, and residential areas for the soldiers.
The formation and specialization of B cells occur in the bone marrow (B cell training academy).
The formation of T cells occurs in the bone marrow but specialization in the thymus (T cell training academy).
CD 4 helper T cells are initially naive. Naive helper T cells are non-functional.
Macrophage acts as a bridge between innate and acquired immune systems. It activates the acquired arm of the immune system.
Naive T cells have receptors for interleukin 12 and interleukin 4.
Macrophage releases interleukin 12, which causes the conversion of naive T cell to Helper T cell 1.
Interleukin 4 from the unknown cells causes the conversion of naive T cell to Helper T cell II.
Helper T cells cause B cells to be active and make immunoglobulin.
Helper T cell 1 releases interleukin II, which causes the activation of cytotoxic T cells.
Cytotoxic T cells kill the pathogen affected cells by releasing perforins, granzymes, and defensins.
The cytotoxic T cell is an effector cell. Helper T cells are not effector cells. They cause cytotoxic T cells, B cells, and innate arm of the immune system to be more active.
The following topics have discussed in the video:
* Overview of the acquired arm of the immune system
* Macrophage as a bridge between the innate and acquired arm of the immune system
* Formation of Helper T cell 1
* Formation of Helper T cell II
* Activation of B cells
* Formation of immunoglobulins
* Activation of cytotoxic T cells
0 Comments